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Article

Expression of variant TMPRSS2/ERG fusion messenger RNAs is associated with aggressive prostate cancer.

Cancer research - 1 Sept 2006

Wang Jianghua, Cai Yi, Ren Chengxi, Ittmann Michael

Abstract excerpt

Recent studies have reported that the majority of prostate cancers express fusion genes in which the 5' region of the androgen-regulated TMPRSS2 gene is fused to an ETS family transcription factor, most commonly the ERG gene. We have characterized in detail the expression of TMPRSS2/ERG fusion mRNAs and correlated the isoforms expressed and expression levels with clinical outcome in cancers from men undergoing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16951141
DOI: 10.1158/0008-5472.CAN-06-1966

Genes

ERG
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression of variant TMPRSS2/ERG fusion messenger RNAs is associated with aggressive prostate cancer.PMID 16951141Read ↗

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Fusion in the ETS gene family and prostate cancerSemantic proximity Read ↗

5' UTR control of native ERG and of Tmprss2:ERG variants activity in prostate cancer.Semantic proximity Read ↗

A sensitive array-based assay for identifying multiple TMPRSS2:ERG fusion gene variants.Semantic proximity Read ↗

Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancerSemantic proximity Read ↗

Overexpression of Prostate-Specific <i>TMPRSS2(exon 0)-ERG</i> Fusion Transcripts Corresponds with Favorable Prognosis of Prostate CancerSemantic proximity Read ↗

Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.Semantic proximity Read ↗

ETS fusion genes in prostate cancerSemantic proximity Read ↗

Expression of TMPRSS2:ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progressionSemantic proximity Read ↗

Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.Semantic proximity Read ↗

Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate CancerSemantic proximity Read ↗

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