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Article

Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.

Oncogene - 19 Apr 2007

Clark J, Merson S, Jhavar S, Flohr P, Edwards S, Foster C S, Eeles R, Martin F L, Phillips D H, Crundwell M, Christmas T, Thompson A, Fisher C, Kovacs G, Cooper C S

Abstract excerpt

TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts...

Read the complete abstract on PubMed

Topics

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Share to Gene Expression Regulation, Neoplastic
Share to TMPRSS2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Oncogene Proteins, Fusion

Share to Prostate

Share to Prostatic Neoplasms

Share to RNA, Messenger

Share to Signal Transduction

Source

Identifiers

PMID: 17043636
DOI: 10.1038/sj.onc.1210070

Genes

ERG
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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