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Article

Effects of folic acid deficiency and MTHFR C677T polymorphism on spontaneous and radiation-induced micronuclei in human lymphocytes.

Mutagenesis - 1 Sept 2006

Leopardi Paola, Marcon Francesca, Caiola Stefania, Cafolla Arturo, Siniscalchi Ester, Zijno Andrea, Crebelli Riccardo

Abstract excerpt

Folic acid plays a key role in the maintenance of genomic stability, providing methyl groups for the conversion of uracil to thymine and for DNA methylation. Besides dietary habits, folic acid metabolism is influenced by genetic polymorphism. The C677T polymorphism of the methylene-tetrahydrofolate reductase (MTHFR) gene is associated with a reduction of catalytic activity and is suggested to modify cancer risk...

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Source

Identifiers

PMID: 16950805
DOI: 10.1093/mutage/gel031

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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