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Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison

3 Nov 2003

Abstract excerpt

DNA double-strand breaks, the most serious DNA lesion caused by ionizing radiation, are also caused by several vitamin or mineral deficiencies, such as for folate. Primary human lymphocytes were either irradiated or cultured at different levels of folate deficiency to assess cell proliferation, apoptosis, cell cycle, DNA breaks, and changes in gene expression. Both radiation and folate deficiency decreased cell...

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PMID: 14597554
DOI: 10.1096/fj.03-0382fje

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