Distinct Substrate and Intermediate Recognition via Mutation Effects on Mycobacterium tuberculosis Methionyl-tRNA Synthetase.

doi:10.1002/prot.70104

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Article

Distinct Substrate and Intermediate Recognition via Mutation Effects on Mycobacterium tuberculosis Methionyl-tRNA Synthetase.

Proteins - 1 May 2026

Thakur Shivani, Mehra Rukmankesh

Abstract excerpt

Tuberculosis kills millions worldwide. Drug-resistance demands exploring new targets against this illness. Methionyl-tRNA synthetase (MetRS) is a crucial target in Mycobacterium tuberculosis (Mtb) that participates in the initiation and elongation of translation and represents a protein of evolutionary interest. To elucidate the structure-function relationships of MetRS, we performed detailed sequence analyses...

Topics

Mycobacterium tuberculosis
Methionine-tRNA Ligase
Molecular Dynamics Simulation
Methionine
Adenosine Triphosphate
Bacterial Proteins
Substrate Specificity
Mutation
Protein Binding
Catalytic Domain
Adenosine Monophosphate
Binding Sites

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Identifiers

PMID: 41392593
DOI: 10.1002/prot.70104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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