Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6.

doi:10.1016/0092-8674(90)90695-b

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Article

Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6.

Cell - 29 Jun 1990

Wilson J B, Weinberg W, Johnson R, Yuspa S, Levine A J

Abstract excerpt

The BNLF-1 gene of Epstein-Barr virus (EBV) encodes the latent membrane protein (LMP), one of the putative oncogene products of the virus. This gene has been expressed from two different enhancer-promoter constructs in transgenic mice, to determine its biological activity and possible contribution to oncogenesis. While transgenic mice expressing LMP in many tissues demonstrated poor viability, expression of LMP...

Topics

Animals
DNA
DNA Probes
Disease Models, Animal
Gene Expression
Herpesvirus 4, Human
Humans
Hyperplasia
Keratins
Membrane Proteins
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins, Viral

Oncogenes

Phenotype

Plasmids

Protein-Tyrosine Kinases

Skin

Source

Open in PubMed

Identifiers

PMID: 1694724
DOI: 10.1016/0092-8674(90)90695-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1694724-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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