Article
Hsp90 at the crossroads of genetics and epigenetics.
Cell research - 1 Sept 2006
Wong Keith S K, Houry Walid A
Abstract excerpt
Hsp90 is a specialized molecular chaperone that is capable of buffering the expression of abnormal phenotypes. Inhibition of Hsp90 activity results in the expression of these phenotypes that are otherwise masked. Selection of offspring from the crossing of affected progenies results in inheritance and enrichment of these phenotypes, which can become independent of their original stimuli. The current combined...
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