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Article

Paraoxonase 1 (PON1) polymorphisms, haplotypes and activity in predicting cad risk in North-West Indian Punjabis.

PloS one - 1 Jan 2011

Gupta Nidhi, Singh Surjit, Maturu V Nagarjuna, Sharma Yash Paul, Gill Kiran Dip

Abstract excerpt

BACKGROUND: Human serum paraoxonase-1 (PON1) prevents oxidation of low density lipoprotein cholesterol (LDL-C) and hydrolyzes the oxidized form, therefore preventing the development of atherosclerosis. The polymorphisms of PON1 gene are known to affect the PON1 activity and thereby coronary artery disease (CAD) risk. As studies are lacking in North-West Indian Punjabi's, a distinct ethnic group with high...

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Identifiers

PMID: 21629682
DOI: 10.1371/journal.pone.0017805
PMCID: PMC3101202

Genes

CAD
PON1

Variants

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