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Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid-induced myelomeningocele

30 Aug 2006

Abstract excerpt

Myelomeningocele (MMC) is the most common cause of neurogenic bladder dysfunction (NBD). We recently developed a novel retinoic acid (RA)-induced MMC model in fetal rats. The objective of this study was to use this model to assess functional and structural characteristics of the detrusor muscle in MMC-associated NBD. Time-dated pregnant Sprague-Dawley rats were gavage fed 60 mg/kg RA dissolved in olive oil or...

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PMID: 16940565
DOI: 10.1152/ajprenal.00001.2006

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