Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women.

doi:10.1359/jbmr.060605

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Article

Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2006

Rivadeneira Fernando, van Meurs Joyce B J, Kant Jojanneke, Zillikens M Carola, Stolk Lisette, Beck Thomas J, Arp Pascal, Schuit Stephanie C E, Hofman Albert, Houwing-Duistermaat Jeanine J, van Duijn Cornelia M, van Leeuwen Johannes P T M, Pols Huibert A P, Uitterlinden André G

Abstract excerpt

UNLABELLED: In this large population-based cohort study, variants in ESR2 were associated with increased risk of vertebral and incident fragility fracture in postmenopausal women. Interaction of ESR2 with ESR1 and IGF1 was determined and revealed a deleterious genetic combination that enhances the risk of osteoporotic fracture. INTRODUCTION: Osteoporosis is a complex disease with strong genetic influence, but the...

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Identifiers

PMID: 16939403
DOI: 10.1359/jbmr.060605

Genes

ESR2
ESR1
IGF1

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