Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes.

doi:10.1001/jama.292.17.2105

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Article

Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes.

JAMA - 3 Nov 2004

Ioannidis John P A, Ralston Stuart H, Bennett Simon T, Brandi Maria Luisa, Grinberg Daniel, Karassa Fotini B, Langdahl Bente, van Meurs Joyce B J, Mosekilde Leif, Scollen Serena, Albagha Omar M E, Bustamante Mariona, Carey Alisoun H, Dunning Alison M, Enjuanes Anna, van Leeuwen Johannes P T M, Mavilia Carmelo, Masi Laura, McGuigan Fiona E A, Nogues Xavier, Pols Huibert A P, Reid David M, Schuit Stephanie C E, Sherlock Rachael E, Uitterlinden André G

Abstract excerpt

CONTEXT: Both bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results. OBJECTIVE: To generate large-scale evidence on whether 3 common ESR1 polymorphisms (intron 1 polymorphisms XbaI...

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Identifiers

PMID: 15523071
DOI: 10.1001/jama.292.17.2105

Genes

ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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