Article
Age-specific effects of estrogen receptors' polymorphisms on the bone traits in healthy fertile women: the BONTURNO study.
Reproductive biology and endocrinology : RB&E - 22 Apr 2009
Massart Francesco, Marini Francesca, Bianchi Gerolamo, Minisola Salvatore, Luisetto Giovanni, Pirazzoli Antonella, Salvi Sara, Micheli Dino, Masi Laura, Brandi Maria Luisa
Abstract excerpt
BACKGROUND: Skeletal characteristics such as height (Ht), bone mineral density (BMD) or bone turnover markers are strongly inherited. Common variants in the genes encoding for estrogen receptor alpha (ESR1) and beta (ESR2) are proposed as candidates for influencing bone phenotypes at the population level. METHODS: We studied 641 healthy premenopausal women aged 20-50 years (yrs) participating into the BONTURNO...
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