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Article

Temperature sensitive influenza A virus genome replication results from low thermal stability of polymerase-cRNA complexes

25 Aug 2006

Abstract excerpt

BACKGROUND: The RNA-dependent RNA polymerase of Influenza A virus is a determinant of viral pathogenicity and host range that is responsible for transcribing and replicating the negative sense segmented viral genome (vRNA). Transcription produces capped and polyadenylated mRNAs whereas genome replication involves the synthesis of an alternative plus-sense transcript (cRNA) with unmodified termini that is copied...

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PMID: 16934156
DOI: 10.1186/1743-422x-3-58

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