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Article

The Wnt signaling pathway has tumor suppressor properties in retinoblastoma.

Biochemical and biophysical research communications - 13 Oct 2006

Tell Shoshana, Yi Hyun, Jockovich Maria-Elena, Murray Timothy G, Hackam Abigail S

Abstract excerpt

Retinoblastoma is a pediatric retinal tumor caused by mutational inactivation of the tumor suppressor pRb. Additional genetic changes, as yet unidentified, are believed to be required for tumor initiation. Mutations in the Wnt signaling pathway have been implicated in the pathogenesis of many cancers. Multiple Wnt pathway genes are expressed in the retina and the pRb and Wnt pathways interact biochemically,...

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Source

Identifiers

PMID: 16930536
DOI: 10.1016/j.bbrc.2006.08.044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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