Article
Variations in the viral NS5B region in Japanese patients with chronic hepatitis C virus genotype 1b infection. No specific amino acid substitution was identified as determinants of treatment response to interferon/ribavirin combination therapy.
Intervirology - 1 Jan 2006
Sugihara Kanji, Orito Etsuro, Tanaka Yasuhito, Kato Takanobu, Lau Johnson Y N, Ohno Tomoyoshi, Hayashi Katsuo, Ogino Masataka, Hirashima Noboru, Sakakibara Kenji, Mizuno Yoshiki, Kato Hideaki, Suzuki Seiji, Ueda Ryuzo, Mizokami Masashi
Abstract excerpt
OBJECTIVE: A recent study suggested that the substitution of amino acid 415 of HCV NS5B from phenylalanine to tyrosine in patients with HCV genotype 1a infection is induced by ribavirin and responsible for resistance to ribavirin therapy. The aim of this study was to evaluate whether specific var...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.