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Article

Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation

23 Aug 2006

Abstract excerpt

Oocytes regulate follicle growth by secreting paracrine growth factors that act on neighbouring granulosa cells (GCs). Those factors identified to date are mainly members of the transforming growth factor-beta (TGFbeta) superfamily, but little is known about which specific receptor/signalling system(s) they employ. This study was conducted to determine the requisite pathways utilised by oocytes to promote GC...

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PMID: 16926195
DOI: 10.1242/jcs.03105

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