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The epidermal growth factor network: role in oocyte growth, maturation and developmental competence

30 Aug 2017

Abstract excerpt

BACKGROUND: The LH surge induces great physiological changes within the preovulatory follicle, which culminate in the ovulation of a mature oocyte that is capable of supporting embryo and foetal development. However, unlike mural granulosa cells, the oocyte and its surrounding cumulus cells are not directly responsive to LH, indicating that the LH signal is mediated by secondary factors produced by the granulosa...

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PMID: 29029246
DOI: 10.1093/humupd/dmx029

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