Article
PKR1 encodes an assembly factor for the yeast V-type ATPase.
The Journal of biological chemistry - 20 Oct 2006
Davis-Kaplan Sandra R, Compton Mark A, Flannery Andrew R, Ward Diane M, Kaplan Jerry, Stevens Tom H, Graham Laurie A
Abstract excerpt
Deletion of the yeast gene PKR1 (YMR123W) results in an inability to grow on iron-limited medium. Pkr1p is localized to the membrane of the endoplasmic reticulum. Cells lacking Pkr1p show reduced levels of the V-ATPase subunit Vph1p due to increased turnover of the protein in mutant cells. Reduced levels of the V-ATPase lead to defective copper loading of Fet3p, a component of the high affinity iron transport...
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