Article
The RAVE complex is an isoform-specific V-ATPase assembly factor in yeast.
Molecular biology of the cell - 1 Feb 2014
Smardon Anne M, Diab Heba I, Tarsio Maureen, Diakov Theodore T, Nasab Negin Dehdar, West Robert W, Kane Patricia M
Abstract excerpt
The regulator of ATPase of vacuoles and endosomes (RAVE) complex is implicated in vacuolar H(+)-translocating ATPase (V-ATPase) assembly and activity. In yeast, rav1 mutants exhibit a Vma(-) growth phenotype characteristic of loss of V-ATPase activity only at high temperature. Synthetic genetic analysis identified mutations that exhibit a full, temperature-independent Vma(-) growth defect when combined with the...
Topics
- Adaptor Proteins, Signal Transducing
- Endosomes
- Golgi Apparatus
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Vacuolar Proton-Translocating ATPases
- Vacuoles
