Article
Aerolysin, a hemolysin from Aeromonas hydrophila, forms voltage-gated channels in planar lipid bilayers.
The Journal of membrane biology - 1 Apr 1990
Wilmsen H U, Pattus F, Buckley J T
Abstract excerpt
The cytolytic toxin aerolysin was found to form ion channels which displayed slight anion selectivity in planar lipid bilayers. In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size. The channels remained open between -70 to +70 mV, but outside this range they underwent voltage-dependent inactivation which was observed as...
Topics
- Aeromonas
- Bacterial Toxins
- Electric Stimulation
- Hemolysin Proteins
- Ion Channel Gating
- Ion Channels
- Lipid Bilayers
- Mutation
- Pore Forming Cytotoxic Proteins
- Zinc