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Article

Increased stability upon heptamerization of the pore-forming toxin aerolysin.

The Journal of biological chemistry - 17 Dec 1999

Lesieur C, Frutiger S, Hughes G, Kellner R, Pattus F, van der Goot F G

Abstract excerpt

Aerolysin is a bacterial pore-forming toxin that is secreted as an inactive precursor, which is then processed at its COOH terminus and finally forms a circular heptameric ring which inserts into membranes to form a pore. We have analyzed the stability of the precursor proaerolysin and the heptameric complex. Equilibrium unfolding induced by urea and guanidinium hydrochloride was monitored by measuring the...

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Source

Identifiers

PMID: 10593978
DOI: 10.1074/jbc.274.51.36722

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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