Article
Mutations affecting pore formation by haemolysin from Escherichia coli.
Molecular & general genetics : MGG - 1 Apr 1991
Ludwig A, Schmid A, Benz R, Goebel W
Abstract excerpt
By introduction of site-specific deletions, three regions in HlyA were identified, which appear to be involved in pore formation by Escherichia coli haemolysin. Deletion of amino acids 9-37 at the N-terminus led to a haemolysin which had an almost threefold higher specific activity than wild-type and formed pores in an artificial asolectin lipid bilayer with a much longer lifetime than those produced by wild-type...
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