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Article

Potent inhibition of human Hepatitis B virus replication by a host factor Vps4.

Virology - 10 Oct 2006

Kian Chua Pong, Lin Min-Hui, Shih Chiaho

Abstract excerpt

Vps4 is a host factor known to be involved in cellular vacuolar protein sorting. We report here that HBV replication and secretion can be significantly inhibited by Vps4 dominant negative, ATPase-defective, mutants K173Q and E228Q. In contrast, wild-type Vps4 at low dose can inhibit HBV replication more effectively in human hepatoblastoma cell line HepG2, than in human hepatoma cell line Huh7. To our knowledge,...

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Share to Adenosine Triphosphatases
Share to ATPases Associated with Diverse Cellular Activities

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endosomal Sorting Complexes Required for Transport

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Source

Identifiers

PMID: 16920176
DOI: 10.1016/j.virol.2006.07.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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