Article
Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2006
Mick Eric, Biederman Joseph, Spencer Thomas, Faraone Stephen V, Sklar Pamela
Abstract excerpt
A polymorphism in the dopamine transporter gene (DAT1) has been previously associated with ADHD and methylphenidate has been hypothesized to block the dopamine transporter. The goal of this study was to examine whether a 40-bp variable number of tandem repeats (VNTR) of DAT1 moderate response and adverse effects associated with methylphenidate treatment of adults with ADHD. Subjects were 106 adults with ADHD...
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