Article
Response to methylphenidate is not influenced by DAT1 polymorphisms in a sample of Brazilian adult patients with ADHD.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Feb 2010
Contini Verônica, Victor Marcelo M, Marques Francine Z C, Bertuzzi Guilherme P, Salgado Carlos A I, Silva Katiane L, Sousa Nyvia O, Grevet Eugenio H, Belmonte-de-Abreu Paulo, Bau Claiton H D
Abstract excerpt
Several lines of evidence suggest a relevant role for the dopamine transporter (DAT1) gene not only as a susceptibility factor for attention-deficit hyperactivity disorder (ADHD), but also as a predictor of individual methylphenidate (MPH) response. Pharmacogenetic studies of MPH response in ADHD have mainly focused on the 40-bp variable number of tandem repeats (VNTR) in the 3' untranslated region (3'-UTR) of...
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