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Article

Mutations that increase the life span of C. elegans inhibit tumor growth.

Science (New York, N.Y.) - 18 Aug 2006

Pinkston Julie M, Garigan Delia, Hansen Malene, Kenyon Cynthia

Abstract excerpt

Mutations in gld-1 cause lethal germline tumors in the nematode Caenorhabditis elegans. We find that a wide variety of mutations that extend C. elegans' life span confer resistance to these tumors. The long life spans of daf-2/insulin-receptor mutants were not shortened at all by gld-1 mutations;...

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PMID: 16917064
DOI: 10.1126/science.1121908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16917064-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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