Article
Autolysins are direct involved in the bactericidal effect caused by penicillin in wild type and in tolerant pneumococci.
FEMS microbiology letters - 1 Jan 1990
López R, Ronda C, García E
Abstract excerpt
The two pneumococcal autolytic enzymes (an N-acetylmuramoyl-L-alanine amidase and an endo-beta-1,4-N-acetylglucosaminidase) are directly involved in the penicillin-induced killing of Streptococcus pneumoniae. The activity of these lytic enzymes was efficiently controlled in tolerant mutants under physiological conditions.
Topics
- Acetylglucosaminidase
- Alleles
- Bacteriolysis
- Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
- Mutation
- N-Acetylmuramoyl-L-alanine Amidase
- Penicillin Resistance
- Penicillins
- Streptococcus pneumoniae