Article
Effect of CYP2D6 genotypes on the metabolism of haloperidol in a Japanese psychiatric population.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2003
Someya Toshiyuki, Shimoda Kazutaka, Suzuki Yutaro, Sato Satoshi, Kawashima Yoshiaki, Hirokane Genta, Morita Sachiyo, Yokono Aya, Takahashi Saburo
Abstract excerpt
We investigated the effect of CYP2D6 genotypes on plasma levels of haloperidol (HAL) and reduced haloperidol (RHAL) in 88 Japanese schizophrenic inpatients being treated with HAL. Some subjects carrying CYP2D6*5 allele (CYP2D6*1/CYP2D6*5, CYP2D6*5/CYP2D6*10) showed extremely high concentrations of both HAL and RHAL, and the groups with CYP2D6*5 allele seemed to have higher plasma concentrations of HAL...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.