Article
CYP2D6*10 alleles are not the determinant of the plasma haloperidol concentrations in Asian patients.
Therapeutic drug monitoring - 1 Aug 2000
Shimoda K, Morita S, Yokono A, Someya T, Hirokane G, Sunahara N, Takahashi S
Abstract excerpt
The authors we investigated the relationship between plasma levels of haloperidol (HAL) and the number of CYP2D6*10 (*10) alleles in 66 Japanese inpatients with schizophrenia (male = 61, female = 5) on HAL. Plasma HAL level was determined by an enzyme immunoassay method. Daily dose of HAL was 1.5-36 (mean +/- SD = 12.3 +/- 7.6) mg or 0.02-0.49 (0.21 +/- 0.13) mg/kg body weight. Plasma HAL levels ranged from 1.4...
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