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Article

Effects of age and the CYP2D6*10 allele on the plasma haloperidol concentration/dose ratio.

Progress in neuro-psychopharmacology & biological psychiatry - 1 May 2003

Ohara Koichi, Tanabu Shigeru, Ishibashi Kazuhisa, Ikemoto Keiko, Yoshida Kimiko, Shibuya Haruo

Abstract excerpt

The authors studied the effect of aging and the CYP2D6*10 polymorphism on the plasma haloperidol (HAL) concentration after chronic administration of HAL. Subjects were 110 Japanese patients (66 male) treated orally with HAL. Venous blood was obtained from each patient for determination of the HAL concentration/dose (C/D) ratio (the plasma concentration of HAL divided by the daily dose of HAL per kilogram body...

Read the complete abstract on PubMed

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Share to Age Factors
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Analysis of Variance

Share to Cytochrome P-450 CYP2D6

Share to Dose-Response Relationship, Drug

Share to Haloperidol

Share to Mental Disorders

Share to Statistics, Nonparametric

Source

Identifiers

PMID: 12691769
DOI: 10.1016/S0278-5846(02)00314-7

Genes

HAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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