Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of smoking and cytochrome P450 2D6*10 allele on the plasma haloperidol concentration/dose ratio.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Sept 2003

Ohara Koichi, Tanabu Shigeru, Yoshida Kimiko, Ishibashi Kazuhisa, Ikemoto Keiko, Shibuya Haruo

Abstract excerpt

OBJECTIVE: This study was carried out to evaluate the influence of CYP2D6 polymorphism and smoking on the plasma clearance of haloperidol (HAL) levels, accounting for the antipsychotic dose, body weight, and coadministration of other drugs. METHODS: Subjects were 110 Japanese patients (66 male, 44 female) diagnosed with schizophrenia, dementia, or mood disorder and treated orally with HAL. Venous blood was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Analysis of Variance

Share to Cytochrome P-450 CYP2D6

Share to Dose-Response Relationship, Drug

Share to Haloperidol

Share to Mental Disorders

Share to Smoking

Source

Identifiers

PMID: 14499311
DOI: 10.1016/S0278-5846(03)00154-4

Genes

HAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of smoking and cytochrome P450 2D6*10 allele on the plasma haloperidol concentration/dose ratio.PMID 14499311Read ↗

Effects of age and the CYP2D6*10 allele on the plasma haloperidol concentration/dose ratio.Semantic proximity Read ↗

Plasma concentrations of haloperidol are related to CYP2D6 genotype at low, but not high doses of haloperidol in Korean schizophrenic patients.Semantic proximity Read ↗

The effect of cytochrome P450 2D6 genotypes on haloperidol metabolism: a preliminary study in a psychiatric population.Semantic proximity Read ↗

Effect of CYP2D6 genotypes on the metabolism of haloperidol in a Japanese psychiatric population.Semantic proximity Read ↗

Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia.Semantic proximity Read ↗

Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic inpatients.Semantic proximity Read ↗

Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients.Semantic proximity Read ↗

Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6.Semantic proximity Read ↗

Importance of the cytochrome P450 2D6 genotype for the drug metabolic interaction between chlorpromazine and haloperidol.Semantic proximity Read ↗

CYP2D6*10 alleles are not the determinant of the plasma haloperidol concentrations in Asian patients.Semantic proximity Read ↗

Effect of a genetic polymorphism of CYP1A2 inducibility on the steady state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia.Semantic proximity Read ↗

Genotyping and phenotyping of CYP2D6 and CYP3A isoenzymes in patients with alcohol use disorder: correlation with haloperidol plasma concentration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.