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The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.

The Journal of biological chemistry - 13 Feb 2004

Roher Alex E, Kokjohn Tyler A, Esh Chera, Weiss Nicole, Childress Jennifer, Kalback Walter, Luehrs Dean C, Lopez John, Brune Daniel, Kuo Yu-Min, Farlow Martin, Murrell Jill, Vidal Ruben, Ghetti Bernardino

Abstract excerpt

One of the familial forms of Alzheimer's disease (AD) encodes the amyloid-beta precursor protein (AbetaPP) substitution mutation V717F. This mutation is relevant to AD research, since it has been utilized to generate transgenic mice models to study AD pathology and therapeutic interventions. Amyloid beta (Abeta) peptides were obtained from the cerebral tissue of three familial AD subjects carrying the AbetaPP...

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PMID: 14645225
DOI: 10.1074/jbc.M311380200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.PMID 14645225Read ↗

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