Article
Embryonic-derived glial-restricted precursor cells (GRP cells) can differentiate into astrocytes and oligodendrocytes in vivo.
Experimental neurology - 1 Sept 2001
Herrera J, Yang H, Zhang S C, Proschel C, Tresco P, Duncan I D, Luskin M, Mayer-Proschel M
Abstract excerpt
We have isolated and characterized a unique glial-restricted precursor cell (GRP) from the embryonic spinal cord. Clonal analysis demonstrated that these cells are able to generate oligodendrocytes and two distinct type of astrocytes (type 1 and type 2) when exposed to appropriate signals in vitro. We now show that many aspects of these cells are retained in vivo. GRP cells are restricted to the glial lineage in...
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