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Article

Evidence for the role of PrP(C) helix 1 in the hydrophilic seeding of prion aggregates.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 1999

Morrissey M P, Shakhnovich E I

Abstract excerpt

Prions are mammalian proteins (PrPs) with a unique pathogenic property: a nonendogenous isoform PrP(Sc) can catalyze conversion of the endogenous PrP(C) isoform into additional PrP(Sc). In this work, we demonstrate that PrP(C) helix 1 has certain properties (hydrophilicity, charge distribution) that make it unique among all naturally occurring alpha-helices, and which are indicative of a highly specific model of...

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Identifiers

PMID: 10500170
DOI: 10.1073/pnas.96.20.11293
PMCID: PMC18027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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