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Article

Influence of the microenvironment on melanoma cell fate determination and phenotype.

Cancer research - 15 Aug 2006

Postovit Lynne-Marie, Seftor Elisabeth A, Seftor Richard E B, Hendrix Mary J C

Abstract excerpt

Tumor cells communicate bidirectionally with the surrounding microenvironment, sending and receiving topographical and molecular cues that direct diverse cellular phenomena, including differentiation, growth, and invasion. The microenvironment has long been acknowledged as a facilitator of melanoma progression, and recent studies have illuminated tumor-associated factors, including hypoxia and the extracellular...

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PMID: 16912153
DOI: 10.1158/0008-5472.CAN-06-0731

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Source receipt: pubmed, retrieved 7 Sept 2026.

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