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Article

Epistatic interactions: how strong in disease and evolution?

Trends in genetics : TIG - 1 Nov 2006

Azevedo Luísa, Suriano Gianpaolo, van Asch Barbara, Harding Rosalind M, Amorim António

Abstract excerpt

When the chimpanzee genome sequence was released, human deleterious alleles associated with simple mendelian diseases were observed as wild-type alleles in six genes (AIRE, MKKS, MLH1, MYOC, OTC and PRSS1). The absence of recognizable phenotypic effects in chimpanzee, contrary to the clinical effect observed in humans, is attributed to epistatic interactions (compensation) between potentially deleterious and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16911842
DOI: 10.1016/j.tig.2006.08.001

Genes

AIRE
MKKS
MLH1
MYOC
OTC
PRSS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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