Article
Cross-comparison of the genome sequences from human, chimpanzee, Neanderthal and a Denisovan hominin identifies novel potentially compensated mutations.
Human genomics - 1 Jul 2011
Zhang Guojie, Pei Zhang, Ball Edward V, Mort Matthew, Kehrer-Sawatzki Hildegard, Cooper David N
Abstract excerpt
The recent publication of the draft genome sequences of the Neanderthal and a ∼50,000-year-old archaic hominin from Denisova Cave in southern Siberia has ushered in a new age in molecular archaeology. We previously cross-compared the human, chimpanzee and Neanderthal genome sequences with respect to a set of disease-causing/disease-associated missense and regulatory mutations (Human Gene Mutation Database) and...
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