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Article

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.

Science (New York, N.Y.) - 18 Oct 2002

Verma Rati, Aravind L, Oania Robert, McDonald W Hayes, Yates John R, Koonin Eugene V, Deshaies Raymond J

Abstract excerpt

The 26S proteasome mediates degradation of ubiquitin-conjugated proteins. Although ubiquitin is recycled from proteasome substrates, the molecular basis of deubiquitination at the proteasome and its relation to substrate degradation remain unknown. The Rpn11 subunit of the proteasome lid subcomplex contains a highly conserved Jab1/MPN domain-associated metalloisopeptidase (JAMM) motif-EX(n)HXHX(10)D. Mutation of...

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Identifiers

PMID: 12183636
DOI: 10.1126/science.1075898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.PMID 12183636Read ↗

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