Article
The complex tale of the achaete-scute complex: a paradigmatic case in the analysis of gene organization and function during development.
Genetics - 1 Jul 2009
García-Bellido Antonio, de Celis Jose F
Abstract excerpt
The achaete-scute gene complex (AS-C) contains four genes encoding transcription factors of the bHLH family, achaete, scute, lethal of scute, and asense located in 40 kb of DNA containing multiple cis-regulatory position-specific enhancers. These genes play a key role in the commitment of epidermal cells toward a neural fate, promoting the formation of both sensory organs in the peripheral nervous system...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Body Patterning
- Cell Communication
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Models, Biological
- Mutation
- Transcription Factors