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Article

KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.

Nature communications - 9 Nov 2015

Cazals Yves, Bévengut Michelle, Zanella Sébastien, Brocard Frédéric, Barhanin Jacques, Gestreau Christian

Abstract excerpt

In the cochlea, K(+) is essential for mechano-electrical transduction. Here, we explore cochlear structure and function in mice lacking K(+) channels of the two-pore domain family. A profound deafness associated with a decrease in endocochlear potential is found in adult Kcnk5(-/-) mice. Hearing occurs around postnatal day 19 (P19), and completely disappears 2 days later. At P19, Kcnk5(-/-) mice have a normal...

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Topics

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Share to Cochlea
Share to Evoked Potentials, Auditory, Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hearing

Share to KCNQ1 Potassium Channel

Share to Potassium

Share to Potassium Channels

Share to Potassium Channels, Inwardly Rectifying

Share to Potassium Channels, Tandem Pore Domain

Source

Open in PubMed Open full text

Identifiers

PMID: 26549439
DOI: 10.1038/ncomms9780
PMCID: PMC4659937

Genes

KCNK5
KCNJ10
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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