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Article

Role of saposin C and D in auditory and vestibular function.

The Laryngoscope - 1 Feb 2016

Lustig Lawrence R, Alemi Sean, Sun Ying, Grabowski Gregory, Akil Omar

Abstract excerpt

OBJECTIVES/HYPOTHESIS: Saposins are small proteins derived from a precursor protein, prosaposin. Each of the four saposins (A-D) is necessary for the activity of lysosomal glycosphingolipid hydrolases. Individual saposin mutations lead to lysosomal storage diseases, some of which are associated with hearing loss. Here we evaluate the effects of the loss of saposins C and D on auditory and vestibular function in...

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Source

Identifiers

PMID: 26198053
DOI: 10.1002/lary.25479

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Related research

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