Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice.

Human molecular genetics - 15 Mar 2003

Gamp Alexander-Christian, Tanaka Yoshitaka, Lüllmann-Rauch Renate, Wittke Dorothee, D'Hooge Rudi, De Deyn Peter P, Moser Tobias, Maier Hannes, Hartmann Dieter, Reiss Karina, Illert Anna-Lena, von Figura Kurt, Saftig Paul

Abstract excerpt

In previous overexpression studies we revealed a role for the lysosomal membrane protein LIMP-2/LGP85 in lysosomal biogenesis. LIMP-2-deficient mice show an increased postnatal mortality which is associated with a development of a uni- or bilateral hydronephrosis caused by an obstruction of the u...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cathepsin D
Share to CD36 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evoked Potentials, Auditory

Share to Lysosomal Membrane Proteins

Share to Receptors, Scavenger

Share to Ureter

Share to Urinary Bladder

Share to Urothelium

Source

Identifiers

PMID: 12620969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12620969-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice.PMID 12620969Read ↗

Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis.Semantic proximity Read ↗

Lysosomal integral membrane protein-2: a new player in lysosome-related pathology.Semantic proximity Read ↗

Variants of LRP2, encoding a multifunctional cell-surface endocytic receptor, associated with hearing loss and retinal dystrophy.Semantic proximity Read ↗

Mutation in the gene encoding lysosomal acid phosphatase (Acp2) causes cerebellum and skin malformation in mouse.Semantic proximity Read ↗

MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse.Semantic proximity Read ↗

Further analysis of the lens phenotype in Lim2-deficient mice.Semantic proximity Read ↗

OCRL regulates lysosomal function and endolysosomal homeostasis in Drosophila nephrocytesSemantic proximity Read ↗

Roles of LIM kinases in central nervous system function and dysfunctionSemantic proximity Read ↗

Kidney Tubular Ablation of Ocrl/Inpp5b Phenocopies Lowe Syndrome Tubulopathy.Semantic proximity Read ↗

Mutations in TJP2 cause progressive cholestatic liver disease.Semantic proximity Read ↗

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuliSemantic proximity Read ↗

The claw paw mutation reveals a role for Lgi4 in peripheral nerve development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.