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Article

Developmental and cell-selective variations in N-methyl-D-aspartate receptor degradation by calpain.

Journal of neurochemistry - 1 Oct 2006

Dong Yi Na, Wu Hai-Yan, Hsu Fu-Chun, Coulter Douglas A, Lynch David R

Abstract excerpt

NMDA receptors play critical roles in synaptic modulation and neurological disorders. In this study, we investigated the developmental changes in NR2 cleavage by NMDA receptor-activated calpain in cultured cortical and hippocampal neurons. Calpain activity increased with development, associated with increased expression of NMDA receptors but not of calpain I. The activation of calpain in immature and mature...

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Identifiers

PMID: 16899064
DOI: 10.1111/j.1471-4159.2006.04096.x
PMCID: PMC2483508

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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