Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quercetin Induces p53-Independent Apoptosis in Human Prostate Cancer Cells by Modulating Bcl-2-Related Proteins: A Possible Mediation by IGFBP-3

1 Feb 2006

Abstract excerpt

Quercetin, a flavonoid found in onion, grapes, green vegetables, etc., has been shown to possess potent antiproliferative effects against various malignant cells. We report insulin-like growth factor-binding protein-3 (IGFBP-3) as an effector of quercetin-induced apoptosis in human prostate cancer cell lines in a p53-independent manner. We evaluated the production of IGFBP-3 in quercetin-treated cells. Apoptosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Growth Hormone and Insulin-like Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16898267
DOI: 10.3727/000000006783981224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quercetin Induces p53-Independent Apoptosis in Human Prostate Cancer Cells by Modulating Bcl-2-Related Proteins: A Possible Mediation by IGFBP-3PMID 16898267Read ↗

Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage.Semantic proximity Read ↗

Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cellsSemantic proximity Read ↗

Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells.Semantic proximity Read ↗

IGFBp-3 prolongs the p53 response and enhances apoptosis following UV irradiationSemantic proximity Read ↗

Flavanols from Japanese Quince (<i>Chaenomeles Japonica</i>) Fruit Inhibit Human Prostate and Breast Cancer Cell Line Invasiveness and Cause Favorable Changes in<i>Bax/Bcl-2</i>mRNA RatioSemantic proximity Read ↗

Insulin-like growth factor (IGF)-binding protein-3 mutants that do not bind IGF-I or IGF-II stimulate apoptosis in human prostate cancer cells.Semantic proximity Read ↗

Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activitySemantic proximity Read ↗

The Putative Oncoprotein Bcl-3 Induces Cyclin D1 To Stimulate G<sub>1</sub> TransitionSemantic proximity Read ↗

Insulin-like growth factor (IGF) binding protein-3 attenuates prostate tumor growth by IGF-dependent and IGF-independent mechanisms.Semantic proximity Read ↗

IGF-Binding Protein-3-Induced Growth Inhibition and Apoptosis Do Not Require Cell Surface Binding and Nuclear Translocation in Human Breast Cancer CellsSemantic proximity Read ↗

Correlation of Insulin-Like Growth Factor-Binding Protein-3 Messenger RNA With Protein Expression in Primary Breast Cancer Tissues: Detection of Higher Levels in Tumors With Poor Prognostic FeaturesSemantic proximity Read ↗

Prognostic significance of Bcl-2 in clinically localized prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.