Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity

1 Oct 2001

Abstract excerpt

Resveratrol has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. In the present study, we determined the effect of high intracellular levels of the anti-apoptosis protein Bcl-2 on caspase-3 activation, PLC-gamma1 degradation and cytochrome c release during resveratrol-induced apoptosis. For this, we used U937/vector and U937/Bcl-2 cells, which were generated by transfection of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to PARP inhibition in cancer therapy
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11577002
DOI: 10.1093/carcin/22.10.1633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activityPMID 11577002Read ↗

Bcl-2 overexpression sensitizes MCF-7 cells to genistein by multiple mechanismsSemantic proximity Read ↗

Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK.Semantic proximity Read ↗

Resveratrol, a tumor‐suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl‐2Semantic proximity Read ↗

Differential regulation of apoptosis in AK-5 tumor cells by the proto-oncogene Bcl-2: presence of Bcl-2 dependent and independent pathways.Semantic proximity Read ↗

Simvastatin inhibits cancer cell growth by inducing apoptosis correlated to activation of Bax and down-regulation of BCL-2 gene expressionSemantic proximity Read ↗

Targeted expression of BCL-2 attenuates MPP+ but not 6-OHDA induced cell death in dopaminergic neuronsSemantic proximity Read ↗

Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis: role of p53 in the ceramide response.Semantic proximity Read ↗

Statins, Bcl-2, and Apoptosis: Cell Death or Cell Protection?Semantic proximity Read ↗

Cleavage of Bcl-2 in oxidant- and cisplatin-induced apoptosis of human melanoma cellsSemantic proximity Read ↗

Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer CellsSemantic proximity Read ↗

Resveratrol-induced Autophagocytosis in Ovarian Cancer CellsSemantic proximity Read ↗

Comparison of Bcl-2 to a Bcl-2 deletion mutant for mammalian cells exposed to culture insults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.