Article
Prognostic significance of Bcl-2 in clinically localized prostate cancer.
The American journal of pathology - 1 May 1996
Bubendorf L, Sauter G, Moch H, Jordan P, Blöchlinger A, Gasser T C, Mihatsch M J
Abstract excerpt
The clinical course of prostate cancer is highly variable and cannot satisfactorily be predicted by histological criteria alone. To study the prognostic significance of Bcl-2 and p53 overexpression in prostate cancer, 137 consecutive radical prostatectomy specimens were examined by immunohistochemistry. Both Bcl-2 and p53 were associated with malignant phenotype. Bcl-2 expression was more frequent in pT3 tumors...
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