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Article

Microbial induction of CARD15 expression in intestinal epithelial cells via toll-like receptor 5 triggers an antibacterial response loop.

Journal of cellular physiology - 1 Nov 2006

Begue B, Dumant C, Bambou J C, Beaulieu J F, Chamaillard M, Hugot J P, Goulet O, Schmitz J, Philpott D J, Cerf-Bensussan N, Ruemmele F M

Abstract excerpt

With the discovery of CARD15 as susceptibility gene for Crohn's disease (CD) a first link to a potential defect in the innate immune system was made. In this work we aimed to analyze enterocyte NOD2/CARD15 expression and regulation in response to bacterial motifs and the consequences of the most...

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Source

Identifiers

PMID: 16897777
DOI: 10.1002/jcp.20739

Genes

NOD2
TLR5
CCL20
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16897777-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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