Article
Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes.
Developmental biology - 1 Mar 1990
Oppenheim R W, Prevette D, Tytell M, Homma S
Abstract excerpt
Treatment of chick embryos in ovo for 10-12 hr with inhibitors of protein and RNA synthesis during the peak time of normal cell death (Embryonic Day 8) for motoneurons and dorsal root ganglion cells markedly reduces the number of degenerating neurons in these populations. The massive neuronal death induced by the early absence of the limbs was also blocked almost completely by these agents. Further, the death of...
Topics
- Animals
- Cell Survival
- Chick Embryo
- Chloroquine
- Curare
- Cycloheximide
- Dactinomycin
- Ganglia, Spinal
- Gene Expression
- Genotype
- Leupeptins
- Microscopy, Electron