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Article

Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth

3 Jun 2013

Abstract excerpt

Tumor suppressors known to date impede cancer growth by arresting the cell cycle or promoting apoptosis. Here we show that unphosphorylated human STAT5A functions as a tumor suppressor capable of repressing multiple oncogenes via heterochromatin formation. Unphosphorylated STAT5A binds to heterochromatin protein 1α (HP1α) and stabilizes heterochromatin. Expressing unphosphorylated STAT5A or HP1α inhibits colon...

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PMID: 23733954
DOI: 10.1073/pnas.1221243110

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