Article
Adenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer.
Gastroenterology - 1 Aug 2006
Miao Xiaoping, Zhang Xuemei, Zhang Lingqiang, Guo Yongli, Hao Bingtao, Tan Wen, He Fuchu, Lin Dongxin
Abstract excerpt
BACKGROUND & AIMS: Adenosine diphosphate ribosyl transferase (ADPRT) and x-ray repair cross-complementing 1 (XRCC1) are major DNA base excision repair proteins acting interactively in repair processes. This study examined the effects of ADPRT Val762Ala and XRCC1 Arg399Gln polymorphisms on ADPRT-XRCC1 interaction in vitro in cells and their contributions to gastric cardia adenocarcinoma (GCA) risk. METHODS: The...
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